Complex control systems, including cyber-physical and cloud control systems, are in open network environments and are often confronted with threats from cyberspace, physical space and even cloud service. With diversified and intelligent attack patterns and improvements in attack capabilities, non-contact damage can be widespread. In this book, the authors use a formal, mathematical approach to introduce their recent research findings to describe and design attack and defense strategies using game theoretic method. The book is divided into three sections, focusing on strategies for resilience against deception attacks and DoS attacks, and protecting cloud control systems against threats. In these sections, the authors address topics such as secure and distributed filtering, attack detection and disturbance rejection, resilient state estimation, and resilient control, and techniques such as Stackelberg games, hierarchical games, and active eavesdropping. Through this book readers will be able to design effective defense strategies for complex control system to achieve resilience for closed-control cyber physical systems, network and cloud systems.